Heart Lady Sabali is a fantastic tragicomedy sprinkled with surreal situations. The film unfolds around a strange journey experienced by Jeannette, the central character of the film.

Jeannette suffers from heart problems, waiting for a new heart leads her strength a quiet life in the suburbs of Montreal. When her boyfriend Bruno continues to make love to her, Jeannette began a love affair with a young colleague. A Malian woman is brutally murdered, Jeannette inherits his heart. After the great transplantation, Jeannette is closely followed by the son of her donor, a teenager of Malian origin, who remain convinced that Jeannette is the reincarnation of his mother. What is yet prove true … almost.